Danofloxacin is a fluoroquinolone antibacterial and antimycoplasmal drug. It acts by inhibition of bacterial DNA-gyrase (an enzyme which is also referred to as topoisomerase II and which is responsible for maintaining the topography of DNA). However it does not significantly inhibit the corresponding mammalian enzyme. Danofloxacin has been proposed for administration in the drinking water to broiler chickens and replacement chicks, and to calves, beef cattle and nonlactating dairy cattle by intramuscular injection, for treatment of respiratory disease.Danofloxacin reaches to peak serum concentration of 0.47 µg/ml after oral administration in 1.5 hours. Its terminal half-life is 6.62 hours and bioavailability is %99.
Danofloxacin is effective on E.coli, Salmonella sp., Enterobacter sp., Serratia sp., Proteus sp., Klebsiella sp., Shigella sp., Yersinia sp., Moraxella sp., Acinobacter sp., Actinobacillus sp., Pasteurella sp., Leptospira sp., Campylobacter sp., Citrobacter sp., Haemophilus sp., Ehrlichia sp., Coxiella brunetti.

Treatment of onic respiratory disease caused by Mycoplasma gallisepticum and Myc. synoviae, sinusitis infection caused by Myc. gallisepticum, respiratory or gastro-intestinal system infections caused by E.coli (sacculitis, colisepticaemia, colibacillosis); enteric and systemic infections caused by Salmonella sp. in chickens.

Pharmacological dosage:5 mg/kg live weight/day for chickens in the treatment of CRD and E.coli infections. 50 mg/kg live weight/day for chicks younger than one week old in Mycoplasma infections
Practical dosage:5 g Danomed/100 kg live weight via drinking water, 50 g Danomed/100 kg live weight for chicks younger than one week old
Treatment period:3 days.

20 gr, 250 gr, 500 gr, 1 kg and 2.5 kg
(More alternative available upon request.)