Pharmacological dosage: 20 -60 mg Chlortetracycline/kg live weight/day

POULTRY and CALVES: Practical dosage: 3-10 g TETRAKLOR / 100 kg live weight.

Treatment period: 5-7 days

To be mixed into drinking water which should be the only water source available.

Must be prepared on a daily basis.

WITHDRAWAL PERIOD: 14 days for poultry and calves.

WARNINGS

“Not for human use.” “Keep out of reach of children.”

STORING AND SHELF LIFE

Store in room temperature, keep away from humidity and light. Shelf life 2 years.

Poultry: onic Respiratory Disease (CRD) (Mycoplasma gallisepticum, Escherichia coli), bluecomb, fowl cholera (Pasteurella multocida), pullorum, infectious synovitis (Mycoplasma synoviae) and sinusitis, hemorrhagic septicemia, Streptococcus and Staphylococcus infections and diarrheae.

Calves: Bacterial enteritis (Escherichia coli, Salmonella spp.), and bacterial pneumonia (Pasteurella spp., Histophilus spp., Klebsiella spp.)

TETRAKLOR is a broad spectrum and bacteriostatic antibiotic. Its active ingredient, Chlortetracycline has the same spectrum with Oxytetracycline and is active against Gram (+) and Gram (-) bacteria, Rickettsia and Mycoplasmas at high doses. Resistance especially to penicillin and streptomycin might be a choice for the treatment Staphylococci. Because chlortetracycline accumulates in the liver and spleen at high doses, it becomes available for the treatment of these organs. Its antibacterial spectrum is as below:

Active against: Gram positive aerobes (Bacillus sp. Corynebacterium sp., Erysipelothrix rhusiopathia, Listeria monocytogenes and Streptococci). Gram negative bacteria (Actinobacillus sp.. Bordetella sp., Francisella tularensis, Haemophilus sp., Pasteurella multocida, P.haemolytica, Yersinia sp., Campylobacter fetus, Borrelia sp. and Leptospira sp. Moraxella bovis). Anaerobes (Actinomyces sp., Fusobacterium sp.) and Mycoplasma sp., Chlamydia sp., Ehrlichia sp., Coxiella brunetii, Ehrlichia, Eperythrozoon and Anaplasmas.

Moderately active against: Staphylococci, Enterococci, Enterobactericeae (Enterobacter sp., E.coli, Klebsiella sp., Proteus sp., Salmonella sp.), Anaerobes (Bacteroides sp and Clostridium sp).

Resistant against: Mycobacterium sp.. Proteus vulgaris, Pseudomonas aeruginosa, Serratia sp., Mycoplasma bovis and M. hyopneumoniae.

Following oral administration chlortetracycline is rapidly absorbed from the gastrointestinal tract with therapeutic plasma concentrations being achieved within 2 to 4 hours, peak plasma concentrations being achieved within 4 to 8 hours and lasted for 6 hours. The half-life is 5,5 hours. Plasma protein binding is 40-50%. Glomerular filtration is its mechanism of urinary excretion via kidneys. A small amount of chlortetracycline is excreted in the bile and milk.