Poultry: onic Respiratory Disease (CRD) (Mycoplasma gallisepticum, Escherichia coli), bluecomb, fowl cholera (Pasteurella multocida), pullorum, infectious synovitis (Mycoplasma synoviae) and sinusitis, hemorrhagic septicemia, Streptococcus and Staphylococcus infections and diarrheae.

Calves: Bacterial enteritis (Escherichia coli, Salmonella spp.), and bacterial pneumonia (Pasteurella spp., Histophilus spp., Klebsiella spp.)

USAGE AND DOSAGE

POULTRY: Pharmacological dosage: 50 mg Tetracycline/kg live weight/day

Practical dosage: 10 g TETRAMED / 100 kg live weight.

RUMINANTS: Pharmacological dosage: 20 mg Tetracycline/kg live weight/day

Practical dosage: 4 g TETRAMED / 100 kg live weight.

Treatment period: 3-5 days

To be mixed into drinking water which should be the only water source available.

Must be prepared on a daily basis. For ruminants don’t mix into milk.

WITHDRAWAL PERIOD: Poultry: Meat:7 days Egg:14 days  Calves: 15 days.

WARNINGS

“Not for human use.” “Keep out of reach of children.”

STORING AND SHELF LIFE

Store in room temperature, keep away from humidity and light. Shelf life 2 years.

TETRAMED, is an antibacterial product. Its active ingredient, tetracycline is a broad-spectrum bacteriostatic agent that inhibits protein synthesis by binding reversibly to receptors of the 30 S ribosomal subunit of susceptible microorganisms. The binding of a tetracycline to the subunit blocks the binding of the aminoacyl-tRNA to the acceptor site on the mRNA-ribosomal complex and prevents the addition of new amino acids to the peptide chain, inhibiting protein synthesis. Its antibacterial spectrum is as below:

Active against: Gram positive aerobes (Bacillus sp. Corynebacterium sp., Erysipelothrix rhusiopathia, Listeria monocytogenes and Streptococci). Gram negative bacteria (Actinobacillus sp.. Bordetella sp., Francisella tularensis, Haemophilus sp., Pasteurella multocida, P.haemolytica, Yersinia sp., Campylobacter fetus, Borrelia sp. and Leptospira sp. Moraxella bovis). Anaerobes (Actinomyces sp., Fusobacterium sp.) and Mycoplasma sp., Chlamydia sp., Ehrlichia sp., Coxiella brunetii, Ehrlichia, Eperythrozoon and Anaplasmas.

Moderately active against: Staphylococci, Enterococci, Enterobactericeae (Enterobacter sp., E.coli, Klebsiella sp., Proteus sp., Salmonella sp.), Anaerobes (Bacteroides sp and Clostridium sp).

Resistant against: Mycobacterium sp.. Proteus vulgaris, Pseudomonas aeruginosa, Serratia sp., Mycoplasma bovis and M. hyopneumoniae.

Tetracyclines are absorbed rapidly following oral administration and distributed widely through the body tissues. They penetrate easily into body fluids and tissues and reach effective levels in a short period of time. Tetracycline accumulates in liver, kidney and bone tissues in high levels. A small amonut is metabolised. It is excreted mainly in urine and feaces.