Florfenicol, a fluorinated derivative of chloramphenicol, acts by inhibiting protein synthesis at the ribosomal level and is bacteriostatic. Florfenicol is a synthetic broad-spectrum antibiotic that is effective against most Gram-positive (Coryneobacterium pyogenes, Streptococcus spp, Staphylococcus spp, Clostridium spp)and Gram-negative (E.coli, Pasteurella haemolytica, P.multocida, Haemophilus somnus, Actinobacillus pleuropneumonia) bacteria. Florfenicol is resistant against enzymatic deactivation because of its Fluor atom and is effective against Gram negative bacteria resistant to antibacterials in the same chemical group. It is especially effective against colibacillosis in poultry caused by E.coli. It is rapidly absorbed from the gastro-intestinal canal and diffuses into the tissues via blood-stream. After a dosage of 20 mg/kg is florfenicol cleared 97% with urine and the rest via feces. It is to 52% unchanged and to 25% oxamic acid and to 7,5 % florfencol base. These compounds also have antibacterial effects.

For the treatment of poultry with E.coli (E.coli respiratory disease, air sacculitis or colicepticemia) and Ornithobacterium rhinotracheale infections.

Pharmacological dosage: 20 mg/kg live weight/day
Practical dosage for 1000 L drinking water:
0-14 days : 235 ml Mediflor 30%
15-30 days : 280 ml Mediflor 30%
31 days – slaughter : 200 ml Mediflor 30%
Treatment period: 5 days

200 ml, 500 ml, 1 L, 2.5 L and 5 L.